Cleanroom System
Shanghai Marya Pharmaceutical Engineering and Project Co., Ltd. founded in 2014 in Shanghai, China, is a total solution provider specializing in engineering design, clean room engineering, pharmaceutical engineering, pharmaceutical equipment, project management and verification, and other technical services.
About Marya
Engineering design team with more than 20 years of experience
Engineering Design
Our experienced engineering team with more than 20 years experience in cleanroom design and construction can ensure that process and materials for your plant is designed and manufactured in the most cost-effective manner with reliablequality to fulfil GMP/FDA/ISO/SGS requirement.
01
Procurement
Maryas’ 3 manufacturing plants for cleanroom projects are all under strict quality management systems certified to ISO9001 with a focus on continuous quality improvement.
02
Construction
Experienced, professional, high-efficiency and strictly stick to the schedule, our installation engineers and workers team have successfully installed more than 300 projects in 51 countries with high customer satisfaction.
03
Service
The R&D and design personnel are composed of experienced senior engineers and technicians Using advanced production and testing equipment with high accuracy.
04
Quality Control
Adhere to the philosophy of “customer-centric”, Marya creates the ultimate service experience with the heart of the craftsman! We are always on the way to create more value for customers.
05
-
![Cleanroom Project]()
Cleanroom ProjectThe main function of a cleanroom is to control the cleanliness, temperature and humidity of the atmosphere to which the products are exposed, so that the products can be produced and manufactured...read more -
![HEPA Filter]()
HEPA FilterThe high efficiency particulate air (HEPA) filter is mainly used to capture dust particles and various suspended matters above 0.5μm. The air purifier is mainly composed of a filter element and a...read more -
![Clean Room Sandwich Panel]()
Clean Room Sandwich PanelClean room sandwich panel is also called cleanroom board, it is a composite board made of color coated board, stainless steel and other materials as the surface material.read more -
![Clean Room Door]()
Clean Room DoorCleanroom doors contribute significantly to contamination control. They are engineered with specialized materials and seals to prevent pollutants from entering or exiting the room. This is vital...read more -
![Clean Room Air Shower]()
Clean Room Air ShowerAn air shower is designed to function as a sort of gateway controller between your cleanroom and the rest of the world.read more -
![Clean Bench]()
Clean BenchA clean bench is an enclosed laboratory bench that is designed to prevent pollution and contamination by controlling and keeping the air cleanliness level at a certain point. It is a type of...read more -
![Pharma Cleanroom]()
Pharma CleanroomMarya is a leading manufacturer and supplier of cleanroom systems, offering comprehensive services such as consulting, design, and construction of cleanrooms. The company specializes in the R&D,...read more -
![Microelectronics Cleanroom]()
Microelectronics CleanroomMicroelectronics cleanroom is a special production environment to ensure product quality and efficiency in microelectronics industry. For this project there are many factors considered such as air...read more -
![The Pharmaceutical Cleanroom]()
The Pharmaceutical CleanroomThe pharmaceutical cleanroom project is a professional design and construction process that provides a clean production environment for pharmaceutical companies. These workshops are often used for...read more -
![HVAC Cleanroom]()
HVAC Cleanroomwho is Marya Shanghai Marya is a pharmaceutical engineering solution provider specializing in pharmaceutical machinery, engineering design, cleanroom projects, project management, and validation....read more -
![Clean Operating Room]()
Clean Operating RoomIn recent years, with the rapid development of medical diagnosis and treatment technology, medical institutions' hardware and software environment has been greatly improved. The clean operating...read more -
![Food Processing Cleanroom]()
Food Processing CleanroomIn recent years, more and more food factories have begun to consider building clean workshops in areas such as inner packaging. Building clean workshops can effectively reduce microbial...read more
Marya as one of the professional HVAC cleanroom project system manufacturers and suppliers in China, we devote ourselves to providing the best service and quality for our customers.
Definition of Cleanroom System
A controlled environment that filters out microscopic pollutants such as dust and dirt, airborne particles, and other microbes, a cleanroom system is a designated area providing the highest levels of cleanliness and hygiene. Typically designed to prevent contamination of highly sensitive materials from external sources, clean rooms are also used to prevent the escape of hazardous biomaterials handled inside. Virology or nuclear research laboratories will typically use the cleanroom as a shield to protect exterior facilities and staff.
Working Principle of Cleanroom System
Cleanrooms make use of airflow and high-tech filters to rid the controlled environment of any particles that could contaminate the research, development, or manufacturing field. Cleanrooms make use of either negative or positive air pressure to control how clean the environment is. A cleanroom with positive air pressure has clean, filtered air pumped into the environment, giving it more pressure than the rooms around it. If the door was opened to the cleanroom accidentally, clean air would be forced out of the cleanroom, blocking any unfiltered air from coming in. A cleanroom with negative air pressure has a lower pressure than the rooms around it. This is achieved by filtering air out of the cleanroom, rather than pumping air in. Negative air pressure cleanrooms are used in cases where the goal is to keep contamination from escaping the environment.
Advantages of Cleanroom System You Want to Know
Reliability
Every cleanroom creates an environment with a direct impact on manufacturing processes and the consistent production of quality products. Without a suitable cleanroom to drive your system, production will be distracted hence delaying delivery to customers. If you desire maximum reliability, boost your cleanroom enclosure system with a cleanroom panel whose standards comply with every health and safety requirement necessary.
Reduce Wastage
Waste management is a crucial concept in the biotech and pharmaceutical industries. You may encounter a period where factories throw batches away due to contaminations. The cleanroom system reduces wastage to a point where our company turns losses into profits rather than misusing resources. A cleanroom panel allows systems to remove daily contaminants that spoil products during production processes or compromise their quality due to unwanted particles that disrupt equipment functions. If a room has the required sterility to impact manufacturing processes positively, then your machine parts cannot be affected, thus minimising waste.
Cost Reduction
Setting up manufacturing equipment costs a lot and it becomes rather expensive if the environment surrounding these machines and their production process becomes contaminated. A cleanroom panel ensures the above benefits occur hence creating various cost-saving mechanisms. It keeps equipment from wearing out, breaking down or contaminating products during the manufacturing processes. Therefore reducing repairs, wastage and quality interferences, thus resulting in cost reductions.
Flexibility
Unlike traditional structures, cleanroom panels provide more sanitary construction. The panels have interconnections enhanced with aluminium profiles for reinforcement and uniform joints. It allows for easy assembly, reconfiguration, installation, upgrades and expansion with less disruption or downtime. Cleanroom panels secure proper maintenance without affecting the entire system hence flexibility. Modular solutions are unlimited in flexibility, not only to transform existing spaces, but also to deploy new facilities.
Consistent Quality
The best part about cleanroom panels is that their design and fabrication aligned with factory-controlled settings. Cleanrooms act as protectors against air and contaminants, therefore one should have a reasonable idea as to why they need a cleanroom. The most vital factor is their modularity hence the need for cleanroom panels. Cleanrooms with modular layout give their systems enough expansion room without disassembling the structure. Plus, when creating a cleanroom, consider all exits, processes, entries and other factors that can lead to contamination.
Simplified Cleaning
If you have ever come across traditional structures of cleanrooms, you understand that they produce many contaminants and particles. Cleanroom panels are quite the opposite of a wide range of cleanroom systems. They do not shed unwanted materials to surfaces, hence less capacity of air contamination. The maintenance and cleaning processes of these panels are simple as well as time saving.
Usage of Cleanroom System
Cleanrooms are a critical part of drug research and manufacturing. The economic viability of pharmaceutical companies depends on their reliability and good reputation. Any error in the manufacturing process or a drop in quality can have dramatic consequences for patients down the line. That is why regulatory bodies like the FDA place great emphasis on process control and good manufacturing practices.
Cleanrooms help drug manufacturers achieve high product quality and meet regulatory standards. Regulatory agencies thus consider cleanrooms an essential part of Good Manufacturing Practices. Failure to comply with such standards can result in costly product recalls and reputational damages.
Preventing contaminations during production also helps manufacturers reduce downtime and streamline operations. Greater efficiency can thus be achieved in controlled environments, contributing to companies' success. Consider products such as antibiotics or vaccinations which are required to be so scientifically precise that the smallest error can be potentially catastrophic. Clean rooms are required for all production areas, from research and manufacturing through to packaging.
Semiconductor manufacturers operate in the realm of nanometers. It is easy to understand why this industry has been the fastest-growing market for cleanrooms globally in the last 10 years. Airborne particles can indeed jeopardize entire batches of semiconductors and lead to lower yields. The reason is they can interfere with the printing of transistors and chips and thus impair performance. To prevent this, most semiconductor manufacturers will use ISO class 1 or 2 cleanrooms for their operations.
Despite drastic precautionary measures, manufacturing equipment, staff, and raw materials are primary sources of indoor contaminants. Industry regulators recommend semiconductor facilities follow ISO 2 or 1 cleanroom standards. In an ISO 1 chamber, only 10 particles larger than 0.1 µm per cubic meter of air are accepted.
Because of the extremely low tolerance to micro-particle pollution, these industries invest a lot of money to build and maintain perfectly air-tight facilities, implementing very strict control policies to reach desired levels of quality and safety.
The two industries we've discussed are the most common places to find cleanrooms, but the list doesn't end there. Where precise specifications are required, a cleanroom is the only option. This means everything from optics and biotechnology to food production, advanced automotive and even nanotech are industries commonly associated with clean rooms.
Cleanroom System Design Principles
Several key design principles contribute to the effectiveness of a cleanroom in controlling contaminants. These principles include air filtration, air pressure control, and temperature and humidity control.
Air Filtration
One of the most critical aspects of cleanroom design is the air filtration system. High-efficiency particulate air (HEPA) filters and ultra-low particulate air (ULPA) filters are commonly used to remove particles from the air.
Air Pressure Control
Maintaining positive air pressure within the cleanroom is essential to prevent the infiltration of contaminants from the surrounding environment. Positive air pressure means that the air pressure inside the cleanroom is higher than the pressure outside, causing air to flow outward when doors or other openings are present. This outward flow of air helps prevent unfiltered air from entering the cleanroom and reduces the risk of contamination.
Temperature and Humidity Control
Controlling temperature and humidity is crucial for maintaining the stability of processes and products within the cleanroom. Excessive temperature or humidity can lead to condensation, corrosion, or other issues that can compromise the cleanliness of the environment.
Cleanroom System Construction
The structure and constructional design of cleanrooms are of paramount importance because they directly impact the ability of the cleanroom to meet its intended purpose. Cleanrooms are designed to control contamination, and the structure and construction of the room play a vital role in this. A well-designed cleanroom will have the following features
Airtight Enclosure
The cleanroom must be an airtight enclosure to prevent the ingress of contaminated air.
HEPA Filtration
The cleanroom must be equipped with high-efficiency particulate air (HEPA) filters to remove airborne contaminants.
Positive Pressurization
The cleanroom must be maintained at a positive pressure relative to the surrounding environment.
Unidirectional Airflow
The cleanroom must have unidirectional airflow, which means that the air flows in one direction only.
Key Components of Cleanroom System Design
Flooring Material
Cleanroom flooring is an essential component working to keep your cleanroom particle-free. In general, most applications use either perforated raised flooring, seamless vinyl, or epoxy paint on concrete. Each of these three flooring material options ensure that no particles are trapped in cracks in the floor, and work to make cleaning as easy as possible.
Filter Types
Filters are likely to be one of the biggest investments you make in your cleanroom design project. There are also three types of filters used most often in cleanrooms:
- Prefilters — Used with both HEPA and ULPA filters, prefilters work to filter out the largest particles in the air. Essentially, they save the bigger, more expensive filters a little work, and ensure you get a bit more bang for your buck.
- HEPA Filters — The most commonly used cleanroom filter, HEPA filters (High-Efficiency Particulate Air filters) work to remove particles 0.3µm or larger. HEPA filters work to filter out 99.99 percent of those particles.
- ULPA Filters — ULPA (Ultra Low Particulate Air filters) are used in applications that require the removal of the smallest particles possible. They remove 99.999 percent of particles larger than 0.12µm.
Lighting Options
If you're new to cleanrooms, you may be surprised to learn how important lighting can be to the overall design of your cleanroom. It's essential to efficient operations within your cleanroom, and it can also have an impact on the overall operating cost of your cleanroom. When designing your cleanroom, a cleanroom design and installation professional will determine how many fixtures you'll need, where those fixtures should go, and how bright your lights will need to be for the best results. Then, you'll be able to choose the type of lighting that works best for you, from fluorescent to incandescent to LED.
Specialty Components
And once you have the basics, like filters, flooring, and lighting, figured out, you'll also want to think about any specialty components of your cleanroom's design. It's good to remember that any cleanroom's greatest enemy is anyone entering or leaving. A well-designed cleanroom will function at its classification standard in perpetuity if no one ever opens the doors. These specialty components help your cleanroom protect against invading particles as your employees enter and exit the controlled environment:
- Airlocks— Airlocks help prevent particles from entering your cleanroom when personnel enter or exit the controlled environment. If your cleanroom requires a high classification standard, or if you're just looking for ways to boost the efficiency and cleanliness of a lower classification cleanroom, an airlock is a great tool. Learn everything you need to know about airlocks here.
- Gowning Rooms— While every cleanroom has a slightly different gowning process, if your employees need to wear special equipment while in the cleanroom, it's a good idea to install a gowning room alongside your cleanroom. This provides a clean space for your employees to don their required personal protection equipment, and can help reduce the number of particles they track into your cleanroom. Here's what you need to know to get started with gowning rooms, and teach your personnel proper gowning procedure.
- Air Showers —Like an airlock, an air shower is an added barrier between your cleanroom and the outside world. Unlike an airlock, an air shower packs an extra punch. Air showers blow filtered air at your employees to “scrub” them of any particulates before they enter the cleanroom. While air showers are often required for higher classifications like ISO Classes 1 and 2, they're a good idea for nearly any cleanroom, as they require your cleanroom system to do less work to keep the environment particulate-free. Here's a bit more information about cleanroom air showers and their cost.
- Pass-Through Chambers— Pass-through chambers are an excellent addition to any cleanroom application that requires you pass materials in and out of the cleanroom on a frequent basis. Easily installed in existing cleanrooms as well as new designs, pass-through chambers make it much easier for your employees to do their work efficiently, without having to de-gown, exit the cleanroom, and then re-gown, just to pass material outside of the controlled environment.
Installing a Modular Cleanroom System
One of the key benefits of investing in a modular cleanroom is that it's so easy to install and assemble. All of the components of a modular cleanroom are built to fit your unique site, perfectly, before they are shipped to you. Here are just a few of the benefits that come with installing a modular cleanroom:
Prefabrication
The most obvious benefit of a modular cleanroom is that all of the components are prefabricated. That means they're built to a standard size so that every component fits perfectly together. You don't have to worry about how your equipment will fit in the cleanroom or if a pass-through chamber is the right size for your space. It is already designed and manufactured for your unique specifications.
Structure to Fit Your Facility
Modular cleanrooms are designed and manufactured to fit your unique facility. Whether your cleanroom will be freestanding or built upon your facility's existing walls, modular cleanrooms are designed with longevity and structure in mind. They won't sag or shift over time, and they're built to fit your space perfectly.
Install in Hours or Days
Since every component of your cleanroom is prefabricated, then deconstructed and shipped to your facility in order, your team can easily install Softwall cleanrooms in just a few hours, and Hardwall or Rigidwall Cleanrooms in as little as two to three days. This ensures your project is up and running in no time at all.
Certifications
Shanghai Marya has received the CE, HTT, Quality Management System, and SGS certificates.
Our Factory
We have three manufacturing bases, covering a total area of about 30000 square meters, including the production of main cleanroom materials and pharmaceutical equipment.
Video Display
Ultimate FAQ Guide to Clean Room Equipment
Q: What is a cleanroom?
Q: How are cleanrooms classified?
Q: What are the key design principles of cleanrooms?
Q: What are the main components of a cleanroom?
Q: Why is monitoring and validation important in cleanrooms?
Q: How much space does a cleanroom take up?
Q: ls it possible to build a cleanroom inside an existing area?
Q: How long does cleanroom construction take?
Q: What is the cleanroom construction process?
Q: What are the main types of cleanroom airflow patterns?
Q: Can cleanroom systems be connected to other facilities or utilities?
Q: Can a cleanroom system be designed for modular construction?
Q: What are the typical maintenance requirements for a cleanroom system?
Q: Are cleanroom systems designed to be fire-safe?
Q: What is a cleanroom Grade A, B, C and D?
Q: What is the difference between positive and negative pressure in cleanrooms?
Q: What is a cleanroom pass-through chamber?
Q: What types of lighting are used in cleanrooms?
Q: Can a cleanroom system be designed to be energy-efficient?
Q: What is a modular cleanroom?
We're well-known as one of the leading cleanroom system manufacturers and suppliers in China. Please feel free to buy high quality cleanroom system made in China here from our factory. For more information, contact us now.
Pill Blister Packing Machine