Common problems and solutions in ampoule sealing

Common problems and solutions in ampoule sealing
The sealing of injectable ampoule generally includes two methods: pull sealing and top sealing, because the finished product produced by the previous method has
The top is smooth, strong, tight and so on, but in the practical application process, many factors will affect the potting
After ampoule quality.
1. Appearance quality problems of ampoule after encapsulation
1.1 Flat head means that the top of the ampoule is clamped flat but not drawn. Cause:
Preheating flame and drawing flame are too small; Pressure ampoule bearing rotation is not flexible or pressure is too small; Individual ampoule wall is too thick. Solution:
Strengthen the front and rear groups of flame fire; Replace the new bearing or adjust the spring inside the ampoule press frame, strengthen the pressure, so that the ampoule can rotate normally, forming wire drawing; Remove unqualified ampoules.
1.2 Pointe refers to the top of the fused ampoule with pointe. Cause:
Drawing flame is too small; The tempering time of ampoule after drawing is too short; The distance between the bottom of the wire drawing clip and the horizontal center line of the flame is too large; Individual ampoule wall is too thick. Solution:
Strengthen the drawing flame intensity; Adjust and control the fire head CAM to prolong the tempering time; Adjust the bottom of the drawing clip slightly higher than the flame horizontal center line about 1 mm distance (mechanical normal position); Remove unqualified ampoules.
1.3 Bubble head is the top of ampoule formed obvious big bubble after sealing, easy to break. Cause:
Drawing flame is too strong; The tempering time of ampoule after drawing is too long; The bottom of the wire drawing clip is slightly lower than the horizontal center line of the flame, although it can be fused, but easy to form a small bubble head. Solution:
Reduce the drawing flame intensity; Shorten the tempering time of ampoule after drawing; Adjust drawing clip to normal distance from flame horizontal center line.
1.4 Dented head refers to the formation of a depression at the top of the ampoule after sealing. Cause:
Ampoule forming bubble head in the process of wire drawing and then cooling contraction; The heating flame is too small to dry some tiny water vapor on the wall of the ampoule, and these low temperature water vapor make the newly formed arc of the top of the ampoule shrink and form a deflated head. Solution:
According to the solution of bubble head for treatment; Strengthen the heating flame, so that the neck of the ampoule is fully heated, so that the tiny water vapor volatilizes as soon as possible.
1.5 Ampule means the top of the ampoule is not sealed. Cause:
Mechanical reasons; Excessive bubble head; Over-dented head.
Solution:
Adjust the drawing clip and flame horizontal center line to the normal distance; The treatment is carried out by the method of bubble head and deflated head.
2. Ampoule burnt head problem
Coke head, refers to the ampoule neck liquid in the process of melting sealing is scorched to form coke spots, light inspection is picked
Divide by.
The causes of sticking liquid on the neck of ampoule are:
The needle is out of position; When the needle exits the ampoule, the remaining drops of the needle stick to the neck wall; The needle enters the ampoule too deeply or too shallowly, resulting in liquid splashing or backspraying to the neck wall during infusion; The needle travel was incorrect. To solve or improve:
Adjust the fixing bolt of the needle so that the needle is in the center of the ampoule mouth when filling; In the drug inlet pipe and connected with a buffer ball, one end is connected with the drug pipe with eight, the other end is closed, the ball memory volume of liquid medicine, or in the drug inlet pipe clamp an adjustable clip to control the amount of medicine, so as to prevent needle residual drip phenomenon; The needle
Change the tip of the head into three or two holes and extend to 1 ~ 2 mm under the neck of the ampoule during infusion. This method can not only overcome the splashing of liquid, but also reduce the residual drip of needle. Adjust the filling CAM in the needle
The head should be extended to the neck of the ampoule and the infusion should be stopped before the needle is lifted to prevent the adhesion of the liquid to the neck wall during the movement of the needle.
Another treatment method is to use the frequency converter to slow down the speed, suitable for high concentration or viscous liquid medicine.
3 Loading problem Common problems:
The load is unstable, and adjusting the load nut does not work. Cause:
Filling apparatus core and coat are not tight; Spring elastic force is not uniform; The dosing device is not fixed in the sleeve. Solution:
Replace the supporting and tight filling device; Replace the new spring; Add a washer or wrap a tape at the contact point between the applicator and the sleeve to fix the applicator in the sleeve; Check regularly whether the adjustable load nut is loose, and remove the bottom of the nut in time.