Introduction
The pharmaceutical water distiller is also called the injection water preparation system, the key system of GMP. The multiple effect water distiller is the key equipment of the currently applied water preparation preparation system. High temperature and high pressure operation is adopted to ensure the stable production of injection pyrogen-free water. The distilled water produced fully meets the requirements of the current US, EU, Japanese and Chinese pharmacopoeia for injection water.
Working Principle
The processes are: the raw material water is heated by the industrial steam in the primary preheater, continuously heated by the secondary steam in each preheaters, and heated by the secondary steam and the distilled water in the condenser, distributed into pipes uniformly by the water separating device at the top of the evaporator and forms film-like flow in the pipes. The film-like flow is evaporated soon because it's thin and forms the secondary steam. The raw water that has not been evaporated is transported to the next effect as the raw water for the secondary-effect evaporator, and the subsequent effects are similar to this. Those that have not been evaporated will enter the next effect, and those that have not been evaporated until the last effect will be discharged as condensated water. The evaporated raw water, now is secondary steam, continues to spiral up in the evaporator, and enters the pure steam pipeline through the special separation device in the upper part, as the secondary heat source;
The secondary steam is condensed into distilled water after being absorbed heat by the secondary effect; the process in each evaporator is similar, distilled water of each effect and secondary steam of the last effect is collected by the condenser and after heat exchange with cooling water and raw material water, it becomes distilled water after cooling. the qualified distilled water will be output as injection water after online conductivity testing, while the unqualified one will be discharged.
The secondary steam transformed from raw water is clean steam undergoing three separation processes: primary separation (the clean water flowing down along pipes after entering the evaporator initially, and evaporating at the same time) → secondary separation (the evaporated raw water, also called the secondary steam, folding back at the lower-end of the evaporator (180° retracement), leaving impurities at the lower part due to gravity) → third separation (the evaporated raw water continuing to spiral up in the evaporator and divided by special dividing devices at the middle and upper parts). Cooled water can only pass through the condenser to cool down distilled water produced at each evaporator and the secondary steam at the last evaporator.
The industrial steam heats raw water in evaporators and preheaters, and then is cooled down and discharged as condensed water. In the condenser, a part of gases that cannot be condensed into water, is called non-condensable gas, which is discharged by the discharge device installed on the upper part of the condenser. Non-condensable gas continuous discharging devices can also be set on each evaporator, depending on the models of each evaporator.
Performance Characteristics
1. Material: The 316L stainless steel is adopted as the material of pressure vessels and pipes directly exposed to distilled water and the secondary pure steam, PTFE is the sealing material, and the 304 stainless steel is the material of other parts including the frame of the machine.
2. Three-level separating unit: Raw water entering the equipment is evaporated by the falling film, divided due to gravity and further divided by special dividing device.
3. Electrochemical polishing: The surface of the stainless steel uses electrochemical polishing to ensure the quality of injection water and to extend the service life the equipment.
4. Double tube plates design: The external preheater, the condenser and multiple effect evaporators all adopt double tube plates design, which is compliance with the GMP requirements and can effectively eliminate the possibility that low-hygienic medium pollute the system.
5. High quality seamless tubes used as heat exchange tubes: The seamless tubes are of better strength and durability and thus can ensure that they can maintain intact condition when processed, welded, thermal expansion and contraction during operation, and ensures that any industrial steam, raw water and cooling water leaks into the clean distilled water and secondary steam side.
6. Three-dimensional elbows: the machine tries to use stainless steel pipes as many as possible to directly stretch elbows to avoid welding.
7. Using automatic welding: the machine tries to use argon to protect the connection of pipelines and parts as much as possible to ensure welding quality.
8. Heat insulation: Both evaporators and preheaters adopt non-chlorine, non-asbestos mineral wool insulation layer and are covered with a stainless steel coating.
9. Economical raw water for preprocessing: Expensive purified water equipment is not required. Raw water can be deionized water or reverse osmosis water with a conductivity of less than 5μS/cm.
10. Economical and energy-saving effects: Because of the step-by-step utilization of the secondary steam in evaporators, the utilization rate of the industrial water is high and the energy-saving effect is obvious. The more is the number of evaporators' effect, the more obvious is the energy-saving effect, and at the same time, the cooling water is also greatly reduced as the evaporators' effect number increases.
11. Control system: PLC (programmable logic controller) automatic control technology is adopted to satisfy different control requirements of different customers. It goes throughout the whole distilled water producing process, from the most basic quality judgement and distribution of distilled water to more advanced operations, including continuous adjustment of media, linkage with the storage system, hierarchical password control, and even the control of evaporation capacity.
12. Paperless recording: Paperless recording is adopted to record the real production situations.
13. Factory test on the performance of the whole machine: The performance of the whole machine is tested by simulating the actual working environment according to the determined procedures in the whole machine test workshop.
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