Prefilled Syringe Filling Sealing Line

Marya PFS filling line is mainly used in the field of biomedicine, suitable for the production and packaging of various sterile high-value products such as vaccines, biological products, biochemical products, antithrombotic drugs, monoclonal antibodies, small molecule heparin, insulin, interferon, rheumatoid arthritis, pharmaceuticals, beauty products(hyaluronic acid), etc. The finished prefilled syringes can also be used for ophthalmic, dental, otological, orthopedic, and gynecological surgical flushing in medical industries.

1. Large filling range, high production capacity and filling accuracy:

(1)Filling range: 1ml-20ml
(2)Capacity: 2000-30000 bph
(3)Filling accuracy: ≤ ± 1% (depending on the characteristics of the medicine)
(4)Applications: 1ml - 20ml (according to user specifications)
(5)Pass rate ≥99.9%
(6)Filling head: 2-10 pcs, choose according to capacity
(7)Various types of filling pump options: metal pump, peristaltic pump, ceramic pump;

(1)Marya's prefilled syringe filling line meets new GMP (and FDA) requirements and ISO standard;
(2)Many control technologies are used to automatically control and monitor the whole production process, such as high precision colored touch screen operation monitoring, PLC automatic control&automatic protection, host frequency conversion speed regulation, etc.;
(3)Adopting servo control system to automatically complete the processes of honeycomb tray unpacking, tearing film, conveying, filling, plug feeding, plug filling and tray output. It's with electromechanical integration control, stable operation and high degree of automation;
(4)Automatic removal and return of the syringe from the honeycomb tray by means of a servo system combined with a cylinder;
(5)During the transport process, there is no friction between the rubber stopper and the contact surface of the liquid medicine and the bottom rail. The stopper is always protected by laminar flow, avoiding the risk of particles and contamination in syringe filling line;
(6)Our main drive components of the machine are servo-driven and are located in the lower part of the machine frame, which allows precise positioning and avoids pollution of the environment;

Marya aseptic prefilled syringe filling line can provide the following optional functions:
(1)Servo motor can be configured to control the filling pump for filling, which has high filling accuracy and easy adjustment;
(2)Configurable filling system CIP/SIP system;
(3)Configurable nitrogen filling unit for isolating the liquid medicine from oxygen;
(4)Configurable vacuum filling system for filling highly viscous products;
(5)Open-RABS/Close-RABS isolation protection system and class 100 air purification laminar flow system;
(6)Function of High-performance no-bottle-no-filling, no-bottle-no-capping and machine stop for bottle jam;
(7)Multi-robot cooperative control technology can be configured to realize the full automation of prefilled syringe film tearing, liner removal, filling, plugging, weighing and other processes;
(8)The automatic calibration of the filling volume can be configured to calibrate the filling volume fully automated;
(9)According to whether the customer's product is toxic or active, a fully closed aseptic isolation (Isolator) system can be configured;